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Related Concept Videos

Brain Imaging01:14

Brain Imaging

216
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
216
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  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Neuroanatomical Profiles Of Cognitive Phenotypes In Patients With Primary Brain Tumors

Neuroanatomical profiles of cognitive phenotypes in patients with primary brain tumors

Jiwandeep S Kohli1, Anny Reyes2, Austin Hopper2

  • 1Department of Psychiatry, University of California San Diego, La Jolla, California, USA.

Neuro-Oncology Advances
|October 3, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Cognitive phenotypes in brain tumor patients reveal distinct brain pathology patterns. These findings link specific impairments to neuroanatomical changes, aiding in understanding and potentially guiding treatment decisions.

Area of Science:

  • Neuroscience
  • Neuroimaging
  • Cognitive Psychology

Background:

  • Brain tumors cause varied cognitive impairments due to multifactorial causes.
  • Cognitive phenotyping classifies patients by impairment patterns, offering a patient-centered approach.
  • Understanding the neuroanatomical basis of these phenotypes is crucial for deciphering impairment mechanisms.

Purpose of the Study:

  • To investigate the neuroanatomical patterns associated with distinct cognitive phenotypes in brain tumor patients.
  • To link structural and microstructural brain changes to specific cognitive impairment profiles.

Main Methods:

  • Prospective, observational study of primary brain tumor patients.
  • Cognitive phenotyping using latent profile analysis identified three groups: generalized, isolated verbal memory, and minimal impairment.
Keywords:
cognitive phenotypescortical thicknessdiffusion tensor imagingneurocognition

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  • Comparison of whole-brain cortical thickness (CT), fractional anisotropy, and mean diffusivity (MD) across phenotypes using structural and diffusion MRI.

    • Main Results:

    • The generalized impairment group exhibited widespread bilateral decreased CT compared to minimal impairment.
    • The verbal memory impairment group showed bilateral temporal lobe decreased CT and increased MD.
    • Increased parahippocampal mean diffusivity correlated with lower verbal memory scores in the verbal memory impairment group.

    Conclusions:

    • Distinct cognitive phenotypes in brain tumor patients correlate with unique patterns of brain pathology.
    • These neuroanatomical differences suggest varying underlying mechanisms for cognitive impairments.
    • Identifying structural and microstructural vulnerabilities can inform targeted treatment strategies.
    neuroimaging