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Longitudinal structural changes in central serous chorioretinopathy: A multimodal imaging-based study.

Niroj Kumar Sahoo1, Joshua Ong2, Amrish Selvam2

  • 1Department of Retina and Vitreous, L V Prasad Eye Institute, Vijayawada, India.

European Journal of Ophthalmology
|October 3, 2024
PubMed
Summary

Longitudinal analysis of central serous chorioretinopathy (CSCR) reveals distinct imaging parameter changes between acute and chronic forms. Chronic CSCR shows increasing retinal pigment epithelium alterations over time, unlike acute CSCR.

Keywords:
CSCRCSROCTRPE alterationsautofluorescencecentral serous chorioretinopathyimaging

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Choroid Diseases

Background:

  • Central serous chorioretinopathy (CSCR) is a condition affecting vision, characterized by fluid accumulation under the retina.
  • Understanding the long-term changes in imaging parameters is crucial for managing CSCR.
  • Previous studies have focused on short-term outcomes, necessitating a long-term observational analysis.

Purpose of the Study:

  • To analyze the longitudinal changes in key imaging parameters in eyes diagnosed with acute or chronic central serous chorioretinopathy (CSCR).
  • To compare the progression patterns of choroidal thickness (CT), double layer sign (DLS), retinal pigment epithelium (RPE) alterations, and hyper-autofluorescence between acute and chronic CSCR over at least four years.

Main Methods:

  • A multicentric, retrospective, longitudinal, observational study was conducted.
  • Data from 175 eyes of 146 patients with CSCR and a minimum four-year follow-up were analyzed.
  • Trends in choroidal thickness, double layer sign area, RPE alterations, and hyper-autofluorescence were evaluated.

Main Results:

  • A decreasing trend in choroidal thickness was observed overall.
  • A steady increase in the double layer sign width and retinal pigment epithelium alterations was noted in the cohort.
  • Chronic CSCR showed an initial rise then fall in hyper-autofluorescence, with a significant correlation between DLS width and hyper-autofluorescence changes.

Conclusions:

  • Acute and chronic CSCR exhibit different longitudinal patterns of imaging parameter changes.
  • Retinal pigment epithelium alterations in acute CSCR did not reach the levels seen in chronic CSCR, even after extended follow-up.
  • Lower central macular thickness and absence of intraretinal fluid at baseline were linked to increased RPE abnormalities.