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Recent Advances in Self-Assembling Peptide-Based Nanomaterials for Enhanced Photodynamic Therapy
Ziyi Zhang1, Runqun Tang1, Xiaoyang Liu1
1State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 211189, China.
Macromolecular Bioscience
|October 3, 2024
Summary
Self-assembling peptide nanomaterials offer enhanced delivery of photosensitizers (PSs) for cancer photodynamic therapy (PDT). These smart materials improve PS stability and tumor targeting, enabling precise and effective cancer treatment.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Cancer Therapy
Background:
- Self-assembling peptide-based nanomaterials offer biocompatibility, biodegradability, and controllability.
- Photosensitizers (PSs) are crucial for photodynamic therapy (PDT) but face challenges in stability, solubility, and targeted delivery.
- Peptide nanomaterials can encapsulate or conjugate PSs to improve their therapeutic efficacy.
Purpose of the Study:
- To review the self-assembly of peptides and their application in developing nanomaterials for cancer PDT.
- To highlight recent advancements in peptide-based nanomaterials for enhanced PDT.
- To provide an outlook on future directions in this field.
Main Methods:
- Review of literature on peptide self-assembly mechanisms and driving forces.
- Analysis of various peptide-based nanomaterials with 0D to 3D nanostructures for PDT.
- Discussion of strategies for photosensitizer delivery and tumor microenvironment responsiveness.
Main Results:
- Peptide self-assembly, driven by various forces, enables the creation of diverse nanostructures.
- Peptide nanomaterials improve PS stability, solubility, tumor accumulation, and reduce dark toxicity.
- Responsive peptide nanomaterials facilitate smart release of PSs for precise PDT.
Conclusions:
- Self-assembling peptide nanomaterials are promising platforms for advanced cancer PDT.
- Tailoring nanomaterial properties enhances PS delivery and therapeutic outcomes.
- Further research can accelerate the development of innovative PDT agents.
