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Celiac disease and nonceliac enteropathies.

John B Doyle1, Benjamin Lebwohl1,2

  • 1Division of Digestive and Liver Diseases, Columbia University Irving Medical Center.

Current Opinion in Gastroenterology
|October 3, 2024
PubMed
Summary

Recent celiac disease research identifies associated conditions and new treatments. New guidelines aid management, while a nocebo effect was noted in nonceliac gluten sensitivity.

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Area of Science:

  • Gastroenterology and Immunology
  • Celiac Disease Research

Background:

  • Celiac disease is an autoimmune disorder triggered by gluten ingestion.
  • Associated conditions include inflammatory arthritis, IBS, and cardiovascular disease.
  • Management and monitoring of celiac disease require updated guidelines.

Purpose of the Study:

  • To review recent research advancements in celiac disease.
  • To highlight new therapeutic developments and clinical guidelines.
  • To discuss findings related to nonceliac gluten sensitivity.

Main Methods:

  • Review of epidemiological studies.
  • Analysis of recently published consensus guidelines.
  • Examination of phase I and phase II clinical trials for pharmaceutical therapies.

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  • Evaluation of a trial on nonceliac gluten sensitivity.

    • Main Results:

    • Continued identification of celiac disease-associated conditions.
    • Publication of new consensus guidelines for patient management.
    • Multiple pharmaceutical therapies for celiac disease are in early-stage trials.
    • A significant nocebo effect was observed in nonceliac gluten sensitivity.

    Conclusions:

    • Recent progress includes updated clinical guidelines and promising new therapeutics for celiac disease.
    • Further high-quality research is essential for improving outcomes in celiac disease and nonceliac enteropathies.