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Lichen striatus: a review.

Astrid Herzum¹, Gianmaria Viglizzo², Corrado Occella²

¹Section of Dermatology, Department of Dermatology and Angioma Center, IRCCS Instituto Giannina Gaslini, Genoa, Italy - astridherzum@yahoo.it.

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|October 3, 2024

Summary

Lichen striatus (LS) is a skin condition primarily affecting children, characterized by linear rashes. While its exact cause is unknown, immune system dysregulation is suspected, and it typically resolves on its own.

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Area of Science:

Dermatology
Pediatrics
Immunology

Background:

Lichen striatus (LS) is an acquired blaschkitis presenting with characteristic linear, unilateral distribution.
LS predominantly affects children and is a self-resolving condition with an unknown etiopathogenesis.

Purpose of the Study:

To review existing literature on Lichen striatus.
To consolidate information on LS patient demographics, clinical presentation, and potential pathogenesis.

Main Methods:

A comprehensive literature review was conducted using PubMed and Google Scholar.
The search keyword used was "lichen striatus" to identify relevant case studies.

Main Results:

The review included 27 articles detailing 440 patients with LS, with a mean age of 3.8 years and a female predominance (1:1.9 ratio).
Clinical diagnosis, based on erythematous or hypopigmented papules along Blaschko lines, was confirmed in 80% of cases. Immune system dysregulation involving cytotoxic T-cells is a potential factor in LS pathogenesis.
The condition typically has a short duration (average 9.5 months) and is often managed conservatively, with topical therapy used in only 20% of cases.

Conclusions:

Lichen striatus is primarily a pediatric dermatosis with a likely immune-mediated etiology.
Further research is needed to fully understand the complexities and pathogenesis of LS due to data limitations.