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Dextroamphetamine-induced changes in regional cerebral blood flow.

R J Mathew, W H Wilson

    Psychopharmacology
    |January 1, 1985
    PubMed
    Summary

    Dextroamphetamine sulfate increased blood pressure and vigor but did not significantly alter regional cerebral blood flow (CBF) in healthy volunteers. A trend towards reduced CBF was observed post-amphetamine, even after CO2 correction.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Psychiatry

    Background:

    • Dextroamphetamine is a stimulant with known effects on cardiovascular and central nervous systems.
    • Understanding its impact on cerebral blood flow (CBF) is crucial for clinical applications and safety.

    Purpose of the Study:

    • To investigate the effects of dextroamphetamine sulfate on regional cerebral blood flow (CBF) in healthy volunteers.
    • To assess changes in physiological parameters and mood states following dextroamphetamine administration.

    Main Methods:

    • 22 healthy volunteers received intravenous injections of 15 mg dextroamphetamine sulfate or saline.
    • Regional cerebral blood flow (CBF), blood pressure, pulse rate, respiratory rate, end-tidal carbon dioxide, and mood were measured before and after injection.

    Main Results:

    • Amphetamine significantly increased systolic blood pressure and vigor, while decreasing end-tidal carbon dioxide.
    • No significant differences in regional cerebral blood flow (CBF) changes were observed between dextroamphetamine and saline groups.
    • A non-significant trend towards reduced CBF was noted after dextroamphetamine, even when corrected for CO2 levels.

    Conclusions:

    • Dextroamphetamine sulfate primarily affects cardiovascular and mood states in healthy individuals.
    • Its direct impact on regional cerebral blood flow (CBF) appears minimal, despite physiological changes.
    • Further research may be needed to explore subtle CBF alterations or effects in different populations.

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