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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Long-term respiratory consequences of prematurity
1Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus University Medical Center- Sophia Children's Hospital, Rotterdam, the Netherlands.
Pediatric Pulmonology
|October 3, 2024
Summary
Preterm birth, affecting 10% of children globally, often leads to lasting respiratory issues and reduced lung function. Even moderate preterm birth impacts lung health, necessitating tailored, multidisciplinary care for affected children.
Area of Science:
- Pediatric Pulmonology
- Neonatology
- Public Health
Background:
- Preterm birth affects approximately 10% of children worldwide.
- Respiratory complications are common sequelae of preterm birth.
- Impaired lung function in preterm infants can persist into adulthood.
Purpose of the Study:
- To highlight the long-term respiratory consequences of preterm birth.
- To emphasize that lung function deficits are observed across the spectrum of prematurity.
- To advocate for phenotype-based management of prematurity-associated lung disease.
Main Methods:
- Review of existing literature on respiratory outcomes in preterm infants.
- Analysis of lung function data in preterm-born children.
- Discussion of the heterogeneity of lung disease in prematurity.
Main Results:
- Preterm birth is associated with increased respiratory symptoms and hospital admissions.
- Lower lung function Z-scores are found in preterm-born children, including those born moderate-late preterm.
- Lung function impairment can extend into adulthood.
Conclusions:
- Preterm birth has significant and lasting impacts on respiratory health.
- Lung function deficits are not limited to extremely preterm infants.
- Multidisciplinary, phenotype-based management is crucial for improving respiratory outcomes in preterm-born individuals.
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