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Ventilation and CO2 response during +Gz acceleration.

U Boutellier, R Arieli, L E Farhi

    Respiration Physiology
    |November 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    During +Gz acceleration, ventilation increases, but alveolar PCO2 drops. This study investigated the mechanisms, finding the CO2 response curve shifts left, not supporting increased CO2 sensitivity during Gz exposure.

    Area of Science:

    • Physiology
    • Aerospace Medicine
    • Cardiopulmonary Responses

    Background:

    • Foot-to-head acceleration (+Gz) causes increased ventilation and decreased alveolar PCO2.
    • The underlying physiological mechanisms for these changes are not fully understood.

    Purpose of the Study:

    • To investigate the mechanisms behind increased ventilation during +Gz exposure.
    • To examine the effect of +Gz on CO2 regulation and sensitivity.

    Main Methods:

    • Non-invasive measurements of ventilation (VE), oxygen consumption (VO2), carbon dioxide production (VCO2), and end-tidal PCO2 (PACO2) in 5 subjects.
    • Cardiac output (Q) and mixed venous CO2 concentration (CVCO2) were measured during exposure to +1, +2, and +3 Gz.
    • Arterial PCO2 (PaCO2) was calculated using Fick's equation.

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    Main Results:

    • Ventilation (VE) increased significantly with increasing +Gz, from 8.7 to 18.0 L/min (air) and 19.6 to 36.9 L/min (5% CO2).
    • End-tidal PCO2 (PACO2) decreased during air breathing (37.9 to 26.9 Torr) but remained relatively stable during CO2 breathing (47.8 to 46.4 Torr).
    • Cardiac output (Q) decreased during air breathing but was maintained during CO2 breathing.

    Conclusions:

    • The observed decrease in PACO2 during +Gz is not fully explained by increased CO2 sensitivity.
    • The data suggest a leftward shift in the CO2 response curve with increasing +Gz.
    • Foot-to-head acceleration does not appear to increase CO2 sensitivity, challenging existing hypotheses.