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Gut-associated lymphoid tissue carcinoma analyzed using next-generation sequencing: A case report
Naomi Sato1, Sadahide Ono1, Kurodo Kamiya2
1Department of Pathology, Iwate Prefectural Central Hospital, Morioka, Iwate 020-0066, Japan.
Pathology, Research and Practice
|October 3, 2024
Summary
Gut-associated lymphoid tissue (GALT) carcinomas (GCs) present unique features. This case study highlights a rectal GC with distinct molecular mutations, suggesting a potential origin independent of conventional colorectal pathways.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Gut-associated lymphoid tissue (GALT) carcinomas (GCs) are recently described tumors with characteristic morphology.
- The origin and pathogenesis of GCs remain controversial, with typical features including submucosal dilated cystic glands and stromal lymphocytes.
Keywords:
Colorectal carcinomaDome-type carcinomaGALT carcinomaGut-associated lymphoid tissueNext-generation sequencing
