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Frailty as a predictor of adverse outcomes in patients with gastric cancer: A systematic review and meta-analysis of 75,357 patients

  • 0Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of China Medical University, Shenyang 110001, China.
Ageing Research Reviews +

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October 3, 2024

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October 3, 2024

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Summary

This summary is machine-generated.

Frailty is common in gastric cancer patients, affecting 27% of individuals. This condition significantly increases mortality and postoperative complications, highlighting the need for routine frailty assessments in gastric cancer care.

Area Of Science

  • Gerontology
  • Oncology
  • Clinical Medicine

Background

  • Frailty is a significant concern in aging populations and is linked to adverse outcomes in gastric cancer (GC) patients.
  • Limited data exists on the prevalence and impact of frailty in individuals with GC.

Purpose Of The Study

  • To determine the prevalence of frailty in gastric cancer patients.
  • To evaluate the association between frailty and mortality and postoperative complications in GC patients.

Main Methods

  • A systematic literature search was conducted across Embase, PubMed, Scopus, and Web of Science up to November 25, 2023.
  • Pooled prevalence, hazard ratios (HR), and odds ratios (OR) for mortality and complications were analyzed using data from eligible studies.

Main Results

  • The meta-analysis included 24 studies with 75,357 GC patients, revealing a frailty prevalence of 27% (95% CI: 24-30%).
  • Frailty was independently associated with increased mortality (adjusted HR = 2.14) and postoperative complications (adjusted OR = 2.65) in GC patients.

Conclusions

  • Frailty is prevalent in gastric cancer patients and significantly worsens patient outcomes.
  • Routine frailty assessment in GC patients is recommended for improved prognostic evaluation and patient management.

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