Related Experiment Video
Updated: Jun 11, 2025
03:05
Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
983
Global Progression Rates of Precursor Lesions for Gastric Cancer: A Systematic Review and Meta-Analysis
Anne I Hahn1, Duco T Mülder2, Robert J Huang3
1Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Summary
Gastric cancer precursor lesions like intestinal metaplasia and dysplasia progress similarly worldwide. This finding suggests surveillance benefits in low-risk areas may match interventions in high-risk regions for these conditions.
Area of Science:
- Gastroenterology
- Oncology
- Epidemiology
Background:
- Gastric cancer (GC) precursor lesions are common, but their progression rates globally are not well understood.
- Variations in incidence rates suggest potential differences in lesion progression between regions.
Purpose of the Study:
- To systematically review and meta-analyze the progression rates of gastric cancer precursor lesions.
- To compare progression rates in countries with low versus medium/high gastric cancer incidence.
Main Methods:
- Systematic review and meta-analysis of studies reporting progression of endoscopically confirmed precursor lesions to GC.
- Stratification of studies based on country GC incidence rates (low <6/100,000; medium/high ≥6/100,000).
- Estimation of progression rates per 1000 person-years for atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia using random-effects models.
Main Results:
- Global pooled progression rates per 1000 person-years were 2.09 for AG, 2.89 for IM, and 10.09 for dysplasia.
- Progression rates for AG were significantly higher in medium/high incidence countries (2.47) compared to low incidence countries (0.97).
- Progression rates for IM and dysplasia showed no significant difference between low and medium/high incidence countries, though dysplasia rates were numerically higher in high-incidence regions.
Conclusions:
- Intestinal metaplasia and dysplasia exhibit similar progression rates globally, irrespective of country incidence.
- Surveillance of these precursor lesions in low-incidence regions may offer comparable benefits to population-wide interventions in high-incidence regions.
- Further prospective research is recommended to validate findings and guide global screening strategies.
Related Concept Videos
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
01:21Barrett Esophagus-I: Introduction
71
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
71
01:27Gastritis-I: Introduction and Types
289
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
289