Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.7K
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

6
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
6
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.5K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

242
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
242
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary fibrosis after COVID-19 is characterized by airway abnormalities and elevated club cell secretory protein-16.

JCI insight·2026
Same author

Risk prediction for lung cancer screening: a systematic review and meta-regression.

European respiratory review : an official journal of the European Respiratory Society·2026
Same author

The association of eicosanoids with lung structure and function: Findings from the Multi-Ethnic Study of Atherosclerosis lung study and Framingham Heart Study.

PloS one·2026
Same author

Circulating monocyte gene expression profiles associated with cardiac remodeling and incident heart failure in the Multi-Ethnic Study of Atherosclerosis.

Communications medicine·2026
Same author

Association of Subclinical Cardiac Remodeling With Incident Cancer in the MESA Cohort.

Journal of the American Heart Association·2026
Same author

The Association of Race and Ethnicity with Six-Minute Walk Distance: The Multi-Ethnic Study of Atherosclerosis.

Ethnicity & disease·2026

Related Experiment Video

Updated: Jun 11, 2025

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
08:17

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

14.3K

Lung structure and longitudinal change in cardiac structure and function: the MESA COPD Study.

Emilia A Hermann1, Yifei Sun2, Eric A Hoffman3

  • 1Department of Medicine, Columbia University Medical Center, New York, NY, USA eah2191@cumc.columbia.edu.

The European Respiratory Journal
|October 3, 2024
PubMed
Summary

This study reveals how lung structure changes affect heart health over time. Increased airway wall area is linked to growing right heart mass, while emphysema is associated with reduced left heart function and cardiac output.

More Related Videos

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
10:33

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Published on: February 3, 2014

27.7K
Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
09:05

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging

Published on: June 21, 2016

18.2K

Related Experiment Videos

Last Updated: Jun 11, 2025

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
08:17

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

14.3K
Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
10:33

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Published on: February 3, 2014

27.7K
Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
09:05

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging

Published on: June 21, 2016

18.2K

Area of Science:

  • Cardiology
  • Pulmonology
  • Medical Imaging

Background:

  • Cross-sectional studies show associations between lung structure and cardiac function.
  • Longitudinal data on the relationship between lung diseases like COPD and cardiac changes are limited.
  • Previous research suggests links between airway disease and cor pulmonale, and emphysema and reduced cardiac output.

Purpose of the Study:

  • To investigate the longitudinal associations between lung structure and cardiac structure and function.
  • To examine how airway wall area and emphysema impact cardiac parameters over a 6-year period.
  • To provide longitudinal data on the interplay between COPD and cardiovascular changes.

Main Methods:

  • Utilized data from the Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study, a longitudinal case-control study.
  • Measured segmental airway wall area (WA) and percent emphysema using computed tomography.
  • Assessed right and left ventricle parameters via cardiac magnetic resonance imaging (cMRI) at baseline and 6-year follow-up.
  • Employed mixed models to analyze longitudinal associations, adjusting for relevant covariates.

Main Results:

  • Greater airway wall area at enrollment correlated with a longitudinal increase in right ventricular mass.
  • Higher percent emphysema was associated with persistently lower left ventricular end-diastolic volume.
  • Increased emphysema was also linked to a stable reduction in cardiac output over the study period.

Conclusions:

  • Cardiac structure and function changes are associated with lung structure over 6 years in a multi-ethnic cohort.
  • Airway wall area is longitudinally associated with increasing right ventricular mass.
  • Emphysema is associated with stable decrements in left ventricular filling and cardiac output.