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Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
Published on: November 15, 2024
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Alcohol and Metabolic Syndrome Interaction
Ryuki Hashida1, Pegah Golabi2, Janus Ong3
1Beatty Liver and Obesity Research Program, Inova Health System, 3300 Gallows Road, Falls Church, VA, USA; Division of Rehabilitation, Kurume University Hospital, Kurume 830-0011, Japan; Department of Orthopedics, Kurume University School of Medicine, Kurume 830-0011, Japan.
Clinics in Liver Disease
|October 3, 2024
Summary
Alcohol and metabolic syndrome are leading causes of chronic liver disease. This review examines how their frequent coexistence impacts liver health outcomes, highlighting a growing global health concern.
Area of Science:
- Hepatology and Gastroenterology
- Metabolic Disorders and Public Health
Background:
- Alcohol-related liver disease (ARLD) and metabolic-dysfunction-associated steatotic liver disease (MASLD) are the predominant causes of chronic liver disease worldwide.
- Global trends show increasing rates of alcohol consumption and metabolic syndrome, often linked to poor diet and inactivity.
- The high prevalence of both conditions leads to frequent co-occurrence in individuals, necessitating a comprehensive understanding of their combined effects.
Purpose of the Study:
- To review the significant impact of alcohol consumption and metabolic syndrome on liver-related health outcomes.
- To synthesize current knowledge on the interplay between ARLD and MASLD when they coexist within the same patient population.
Main Methods:
- Literature review synthesizing existing research on alcohol-related liver disease.
- Analysis of studies investigating metabolic syndrome and its components in relation to liver health.
- Examination of research focusing on the combined effects of alcohol and metabolic syndrome on liver outcomes.
Main Results:
- Both excessive alcohol intake and metabolic syndrome are independently associated with severe liver conditions.
- The co-occurrence of alcohol use and metabolic syndrome exacerbates liver damage and progression of liver disease.
- Individuals with both conditions face a significantly higher risk of adverse liver-related outcomes compared to those with only one condition.
Conclusions:
- The combined burden of alcohol and metabolic syndrome poses a substantial threat to liver health globally.
- Integrated management strategies addressing both alcohol consumption and metabolic factors are crucial for mitigating liver disease progression.
- Further research is warranted to elucidate the precise mechanisms underlying the synergistic negative effects on the liver.
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