Myopic shift in female mice after ovariectomy
Yan Zhang1,2, Kiwako Mori1,2, Heonuk Jeong1,2
1Laboratory of Photobiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160- 8582, Japan.
Scientific Reports
|October 3, 2024
Summary
Female sex hormones influence myopia development. Ovariectomy in female mice exacerbated myopia, suggesting a protective role of these hormones against myopia progression.
Area of Science:
- Ophthalmology
- Endocrinology
- Genetics
Background:
- Myopia is a global health issue with higher prevalence in women.
- The connection between sex hormones and myopia is not fully understood.
- Investigating sex hormones' role in myopia is crucial for understanding its development.
Purpose of the Study:
- To investigate the relationship between sex hormones and myopia development.
- To determine the impact of ovarian hormones on myopia progression in female mice.
- To compare myopia development between male and female mice.
Main Methods:
- Lens-induced myopia (LIM) surgeries were performed on male and female mice.
- Bilateral ovariectomy (OVX) was conducted on female mice to remove ovaries.
- Ocular parameters were measured to assess myopia progression in OVX and control groups.
Main Results:
- Male mice exhibited higher myopia and faster axial elongation than female mice.
- Ovariectomy in female mice led to myopic refraction, but axial length changes were not significant.
- Combined LIM and OVX magnified myopic refraction in female mice, with increased anterior chamber depth.
Conclusions:
- Female sex hormones play a regulatory role in myopia development.
- Hormonal changes, particularly the absence of ovarian hormones, can influence myopia progression.
- Further research is needed to elucidate the precise mechanisms of sex hormone action on ocular development and myopia.
