Related Experiment Video

Updated: Jun 11, 2025

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

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Tumor necrosis factor superfamily signaling: life and death in cancer

Obada Ababneh1, Daisuke Nishizaki2, Shumei Kato2

  • 1Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan. oeababneh185@med.just.edu.jo.

Cancer Metastasis Reviews
|October 3, 2024
PubMed

Insights

Tumor necrosis factor (TNF) superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) members have complex roles in cancer. This review explores their dual pro- and anti-tumor activities and signaling pathways in cancer cells.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, but response rates remain limited.
  • Many patients treated with ICIs experience primary resistance or subsequent disease progression.
  • Tumor necrosis factor (TNF) superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) members are key regulators of immune responses and cellular fate, with complex roles in cancer.

Purpose of the Study:

  • To review the multifaceted roles of TNFSF/TNFRSF members in cancer.
  • To highlight specific TNFSF/TNFRSF members, particularly those involved in cell death and co-stimulation.
  • To elucidate their signaling pathways and impact on cancer cell survival and death.

Main Methods:

  • Literature review of TNFSF/TNFRSF family members in cancer research.
  • Focus on death domain-containing and co-stimulatory members.
  • Analysis of signaling pathways implicated in cancer biology.

Main Results:

  • TNFSF/TNFRSF molecules exhibit context-dependent pro- or anti-tumoral activities.
  • TNF acts as a dual mediator in oncogenesis.
  • While anti-TNF agents are established for autoimmune diseases, their direct anti-cancer applications are less defined.

Conclusions:

  • TNFSF/TNFRSF members represent a complex and promising area for cancer therapeutic development.
  • Understanding their intricate signaling is crucial for harnessing their potential in cancer treatment.
  • Further research is needed to clarify their precise roles and therapeutic applications in oncology.
Keywords:
CancerImmunotherapyNovel immunotherapy targetsPersonalized oncologyTNFRSFTNFSFTumor necrosis factor

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