Chronic phospholipid liposomes administration and ovarian function

In the past years, hypothalamic phospholipids (H-PL) have been used therapeutically for their behavioral effects. The major pharmacological effect of H-PLs is that they increase the turnover rate of biogenic amines in the brain. Previous studies have also shown that a single i.v. dose of H-PL may influence tha plasma levels of gonadotropins, prolactin (PRL) and growth hormone (GH). Since data have not yet been published concerning the effects, if any, of chronic i.m. administration of H-PL on the ovarian function, the present study was undertaken to gain insight into this issue. Four women were studied. Each subject was given H-PLs by i.m. injection from the 5th to the 20th day of the cycle at the dose of 100 mg/day. Blood samples were repeatedly taken over this period to measure the plasma concentrations of FSH, LH, E2, PRL, and progesterone. GH administration, no side-effects were noted in any of the subjects studied. All subjects presented normal plasma levels of FSH, LH, E2, PRL, and progesterone. GH demonstrated some upward fluctuations, which always regressed rapidly. Our findings demonstrate that chronic H-PL administration at therapeutic doses does not influence the ovarian cycle in women. In the light of our data, it appears that different hormonal effects are elicited by a single i.v. high-dose administration of H-PLs as compared with those produced by chronic i.m. treatment at therapeutic doses.