Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

329
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
329
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

386
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
386
Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

414
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
414
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

753
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
753
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

987
Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
987
Non-Oral Extravascular Drug Absorption Routes01:15

Non-Oral Extravascular Drug Absorption Routes

202
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
202

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined periodontitis GWAS identifies LINC01541 as a regulator of innate immunity in the oral mucosa.

Human molecular genetics·2026
Same author

Validity of a Commercially Available Inertial Measurement Unit for Artificial Intelligence-Based Trick Detection and Kinematic Performance Assessment in Skateboarding.

Sensors (Basel, Switzerland)·2026
Same author

Osteopathic manipulative treatment and cervicogenic headache: a randomized controlled trial.

Journal of osteopathic medicine·2026
Same author

Oral virome in health and disease.

Journal of the American Dental Association (1939)·2026
Same author

Management of Periodontal Abscesses and Endodontic-Periodontal Lesions-A Systematic Review.

Journal of clinical periodontology·2026
Same author

Towards Continuous Swim Leg Analytics in Olympic Triathlon: A Systematic Review of Sensor-Based Assessment Approaches in Open-Water Sports Contexts.

Sensors (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jun 11, 2025

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

11.1K

Topical Application of Dexamethasone-Loaded Core-Multishell Nanocarriers Against Oral Mucosal Inflammation.

Cynthia V Yapto1,2,3, Keerthana Rajes2, Antonia Inselmann1,3

  • 1Institute of Biochemistry, Charité - Universitätsmedizin Berlin, 10117, Berlin, Germany.

Macromolecular Bioscience
|October 4, 2024
PubMed
Summary

Catechol-functionalized core-multishell (CMS) nanocarriers demonstrate superior mucoadhesion and anti-inflammatory effects for oral diseases compared to non-functionalized variants. This advanced drug delivery system overcomes saliva challenges for improved topical treatment efficacy.

Keywords:
core‐multishell nanocarrierdexamethasonedrug deliveryepithelial cellsoral mucosal inflammation

More Related Videos

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
07:33

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

1.7K
Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

14.9K

Related Experiment Videos

Last Updated: Jun 11, 2025

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

11.1K
Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
07:33

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

1.7K
Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

14.9K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Pharmaceutics

Background:

  • Topical treatment of oral inflammatory diseases faces challenges due to mucosal barriers and saliva, limiting drug bioavailability.
  • Nanocarrier technology offers an innovative solution for enhanced topical drug delivery to the oral mucosa.
  • Core-multishell (CMS) nanocarriers show promise for oral mucosal drug delivery due to biocompatibility and adhesion properties.

Purpose of the Study:

  • To evaluate and compare the properties of ester-based CMS nanocarriers (CMS-NC) with catechol-functionalized variants (CMS-C0.08).
  • To assess the impact of catechol functionalization on nanocarrier mucoadhesion in the presence of saliva.
  • To determine the anti-inflammatory efficacy of dexamethasone-loaded CMS nanocarriers for oral mucosal diseases.

Main Methods:

  • Synthesis and characterization of ester-based CMS nanocarriers (CMS-NC) and catechol-functionalized CMS nanocarriers (CMS-C0.08).
  • In vitro evaluation of nanocarrier mucoadhesion in simulated saliva.
  • In vitro assessment of anti-inflammatory efficacy of dexamethasone-loaded nanocarriers (Dx-CMS-NC and Dx-CMS-C0.08) under dynamic conditions.

Main Results:

  • CMS-C0.08 exhibited significantly improved mucoadhesion compared to CMS-NC, especially in the presence of saliva.
  • Saliva inhibited the mucoadhesion of CMS-NC but not CMS-C0.08.
  • Dexamethasone-loaded CMS-C0.08 demonstrated a superior anti-inflammatory effect compared to dexamethasone-loaded CMS-NC during dynamic application.

Conclusions:

  • Catechol functionalization enhances the mucoadhesion of CMS nanocarriers in the challenging oral environment.
  • CMS-C0.08 represents a superior drug delivery system over CMS-NC for treating oral mucosal diseases.
  • The improved adhesion properties of Dx-CMS-C0.08 translate to enhanced therapeutic efficacy for topical oral treatment.