The application of mass defect percentage in the evaluation of acute coronary syndrome
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Published on: August 9, 2024
Man Zhang1, Yinuo Sun, Limeng Zhang
1Department of Nuclear Medicine, The First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, 250014, China.
Insights
Myocardial perfusion mass defect percentage (MDP) in gated myocardial perfusion imaging (G-MPI) correlates with inflammatory markers and cardiac function in acute coronary syndrome (ACS) patients. This finding may aid in evaluating and treating ACS.
Area of Science:
- Cardiology
- Nuclear Medicine
- Hematology
Background:
- White blood cell counts, including neutrophils and lymphocytes, and their ratios, are linked to cardiac events in coronary disease.
- The relationship between myocardial perfusion mass defect percentage (MDP) from gated myocardial perfusion imaging (G-MPI) and these hematological parameters in acute coronary syndrome (ACS) is not well understood.
Purpose of the Study:
- To investigate the correlation between MDP derived from G-MPI and hematological parameters in ACS patients.
- To explore the utility of MDP in evaluating ACS.
Main Methods:
- Thirty-six ACS patients underwent resting-state G-MPI (SPECT/CT).
- Myocardial perfusion MDP was quantified as the percentage of left ventricular mass with abnormal perfusion.
- Correlations were assessed between MDP and white blood cell count, neutrophil count, lymphocyte count, neutrophil-to-lymphocyte ratio (NLR), and cardiac function parameters (summed rest score, ejection fraction, end-systolic volume, end-diastolic volume).
Main Results:
- Myocardial perfusion MDP showed significant correlations with white blood cell count, neutrophil count, and NLR (P < 0.01).
- Hematological parameters differed significantly between low and high MDP groups.
- MDP negatively correlated with end-systolic volume (r = -0.615) and left ventricular ejection fraction (r = -0.657).
Conclusions:
- Myocardial perfusion MDP is strongly correlated with inflammatory cell counts and cardiac function parameters obtained via G-MPI in ACS.
- MDP may serve as a valuable tool for the evaluation and management of ACS patients.
Objectives:
White blood cells, neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio (NLR) distribution patterns in patients with anatomic coronary disease have previously been associated with cardiac events such as myocardial infarct size, complications, and prognosis. However, it remains unknown whether myocardial perfusion mass defect percentage (MDP) obtained from gated myocardial perfusion imaging (G-MPI) correlates with these hematological parameters. Therefore, our research aimed to investigate the application of MDP in the evaluation of acute coronary syndrome (ACS).
Methods:
Thirty-six patients with ACS underwent single-photon emission computed tomography/computed tomography using retrospective electrocardiography gating during the resting state. The primary outcome was the percentage of left ventricular mass with abnormal myocardial perfusion (i.e. MDP) in G-MPI. Furthermore, the correlation between myocardial perfusion MDP and lymphocyte count, neutrophil count, white blood cell count, and NLR was calculated. In addition, we explored the relationship of myocardial perfusion MDP with other cardiac function parameters obtained from G-MPI, such as summed rest score, left ventricular ejection fraction, end-systolic volume, and end-diastolic volume.
Results:
Myocardial perfusion MDP significantly correlated with white blood cell count, neutrophil count, and NLR ( P < 0.01). Furthermore, these hematological parameters were significantly different between low and high MDP groups. Additionally, myocardial perfusion MDP negatively correlated with end-systolic volume ( r = -0.615) and left ventricular ejection fraction ( r = -0.657).
Conclusion:
Myocardial perfusion MDP has a high correlation with inflammatory cell counts and cardiac function parameters obtained from G-MPI in ACS; this may be of help in the evaluation and treatment of these patients.
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