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Multistep modeling applied to a Malaysian ALS registry
David Paul Capelle1, Wafa Sabirin1, Nurul Angelyn Zulhairy-Liong1
1Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia and.
Objective:
To apply the multistep model of pathogenesis in amyotrophic lateral sclerosis (ALS) to data from a multiethnic Malaysian registry.
Methods:
Clinical data, including age at symptom onset, was collected from 289 patients who presented to our multidisciplinary clinic from 2016 until 2024. A least squares linear regression model was constructed from the logarithm of approximated incidence and the logarithm of age. Population incidence was approximated by adjusting the absolute numbers of patients in 5 year groups by the size of the general population in the respective age group.
Results:
A linear relationship between log of incidence versus log of age was observed, with a slope of 4.57 (95% CI, 3.3-5.8) and an r2 value of 0.93, suggesting a 6-step process.
Conclusion:
Progression toward symptom onset in Malaysian ALS patients appears consistent with a multistep model of disease as observed in other cohorts.
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