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Updated: Jun 11, 2025

Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line
Published on: February 8, 2022
Ironing Out the Kinks: Arming Natural Killer Cells against Ovarian Cancer
Hannah Noelle Bell1,2, Weiping Zou1,3,2,4,5
1Department of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan.
Abstract:
Ameliorating the tumor immune microenvironment is a key strategy to improve the therapeutic outcomes of patients with cancer. Sandoval and colleagues demonstrate that iron chelation enhances type I IFN production, promotes NK cell tumor trafficking and activation, and synergizes with chemotherapy drug cisplatin to reduce metastatic ovarian cancer progression in murine models. See related article by Sandoval et al., p. 1901.
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