Predictors of recurrence and patterns of failure among patients treated with nephroureterectomy for upper tract urothelial carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Recurrence after nephroureterectomy for upper tract urothelial carcinoma (UTUC) is common. Locoregional/intravesical recurrence is the main pattern, highlighting the need for targeted adjuvant therapies.
Area Of Science
- Urology
- Oncology
- Cancer Research
Background
- Upper tract urothelial carcinoma (UTUC) recurrence rates post-nephroureterectomy (NU) are high.
- Adjuvant therapies targeting high-risk sites may improve long-term outcomes for UTUC patients.
Purpose Of The Study
- To describe patterns and predictors of UTUC recurrence after NU.
- To identify patient, disease, and treatment factors associated with recurrence.
Main Methods
- Retrospective review of 113 patients treated with NU for UTUC (2006-2013).
- Kaplan-Meier analysis for time to locoregional (LR), intravesical (IV), and distant recurrence.
- Cox Proportional Hazards models to identify predictors of LR/IV and LR recurrence.
Main Results
- 42% of patients experienced disease recurrence.
- Intravesical (24%) and locoregional (19%) recurrence were the most common patterns.
- Advanced T stage (T3/4) and lymphovascular space invasion (LVSI) were observed in 36% and 19% of patients, respectively.
- History of prior bladder disease predicted LR/IV recurrence.
Conclusions
- Locoregional/intravesical recurrence is the predominant failure pattern in UTUC post-NU.
- Understanding recurrence patterns and predictors is crucial for developing effective adjuvant therapies.
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