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Review on Recent Advance of 3DP-Based Pediatric Drug Formulations

Aychew Mekuriaw Tegegne1, Kassahun Dires Ayenew1, Muluken Nigatu Selam2

  • 1Department of Pharmacy Medicine and Health Science College Debre Berhan University, Debre Berhan, Ethiopia.

Biomed Research International
|October 4, 2024
PubMed

Insights

Three-dimensional printing (3DP) offers personalized medicine solutions, particularly for pediatric patients. This technology enables customized drug formulations to improve treatment adherence and efficacy in diverse patient groups.

Area of Science:

  • Pharmaceutical Sciences
  • Biomedical Engineering
  • Drug Delivery Systems

Background:

  • Individualized therapy is crucial, especially for the diverse pediatric population with unique physiological needs.
  • Developing suitable dosage forms for children presents significant challenges for the pharmaceutical industry.
  • Treatment adherence is vital for safe and effective pharmacotherapy in pediatric patients.

Purpose of the Study:

  • To review the application of three-dimensional printing (3DP) in developing pediatric-friendly drug formulations.
  • To highlight how 3DP facilitates individualized therapy for various patient groups.
  • To explore the potential of 3DP in optimizing drug dosage regimens.

Main Methods:

  • Review of widely used three-dimensional printing technologies in pharmaceutical formulation.
  • Analysis of 3DP applications for creating customized pediatric dosage forms.
  • Exploration of 3DP's role in addressing needs of special populations and drugs with complex pharmacokinetics.

Main Results:

  • Three-dimensional printing (3DP) offers a versatile platform for novel pharmaceutical formulation development.
  • 3DP enables the creation of patient-specific dosage forms, improving therapeutic outcomes.
  • The technology is adaptable for optimizing regimens in pediatrics, geriatrics, and patients with organ impairment or specific pharmacokinetic profiles.

Conclusions:

  • Three-dimensional printing (3DP) is a transformative technology for personalized medicine in pharmaceuticals.
  • Its application in pediatric drug formulation holds significant promise for enhancing treatment adherence and efficacy.
  • Advancements in 3DP technology and pharmaceutical inks pave the way for widespread patient dosage form customization.

Keywords:
3DP technologydosage formindividualized therapypediatric formulation

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