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Corrigendum: Neurophysiological hallmarks of Huntington's disease progression: an EEG and fMRI connectivity study

Natalya V Ponomareva1,2, Sergey A Klyushnikov1, Natalia Abramycheva1

  • 1Research Center of Neurology, Moscow, Russia.

Frontiers in Aging Neuroscience
|October 4, 2024
PubMed

Insights

This study corrects a previous article DOI. It ensures accurate citation and retrieval of research on neurodegenerative diseases and aging.

Area of Science:

  • Neuroscience
  • Gerontology

Keywords:
CAG repeatsEEGHTT geneHuntington's diseasecognitive functionsfunctional MRIpreclinical stage

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Huntington Disease l: Introduction01:21

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...