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Related Concept Videos

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Related Experiment Video

Updated: Jun 11, 2025

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Immune triggers preceding neuralgic amyotrophy.

Davide Sparasci1, Lenka Schilg-Hafer2, Bettina Schreiner3

  • 1Department of Neurology, Neurocenter of Southern Switzerland EOC, Lugano, Switzerland.

European Journal of Neurology
|October 4, 2024
PubMed
Summary
This summary is machine-generated.

Infections and vaccinations can trigger neuralgic amyotrophy (NA). About 39% of NA cases were preceded by confirmed immune triggers like infections or COVID-19 vaccination, suggesting a link.

Keywords:
Parsonage–Turner syndromeimmune triggerinfectionneuralgic amyotrophyvaccination

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Area of Science:

  • Neurology
  • Immunology
  • Infectious Diseases

Background:

  • Neuralgic amyotrophy (NA) is a rare neurological disorder.
  • The precise infectious or vaccination-related triggers for NA remain unclear.

Purpose of the Study:

  • To investigate the frequency and type of preceding infectious agents and vaccinations in patients with neuralgic amyotrophy.
  • To identify potential immunological triggers for NA.

Main Methods:

  • A multicenter, prospective, observational, matched case-control study.
  • NA diagnosis by neuromuscular experts using clinical and electrodiagnostic criteria.
  • Serological testing for various viruses, bacteria, and vaccination status in NA patients and controls.

Main Results:

  • Out of 57 NA patients, 15 (26.3%) had a confirmed symptomatic infectious trigger.
  • COVID-19 vaccination was a potential trigger in 7 (12.3%) patients.
  • Acute viral infections were significantly associated with bilateral brachial plexus involvement (p=0.003).

Conclusions:

  • Confirmed immune triggers (infection or vaccination) preceded disease onset in 38.6% of NA cases.
  • Testing NA patients for intracellular antigens in the acute phase is recommended, especially with bilateral involvement or hepatitis.