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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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  1. Home
  3. Role And Clinical Value Of Serum Hsa_tsr011468 In Lung Adenocarcinoma.
  1. Home
  3. Role And Clinical Value Of Serum Hsa_tsr011468 In Lung Adenocarcinoma.

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Role and clinical value of serum hsa_tsr011468 in lung adenocarcinoma.

Ping Zhao1, Kui Zhu1, Cuihua Xie2

  • 1Department of Laboratory Medicine, Nantong First People's Hospital and The Second Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu 226001, P.R. China.

Molecular Medicine Reports
|October 4, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Transfer RNA-derived small RNAs (tsRNAs) show promise as biomarkers. This study found hsa_tsr011468, a tsRNA, is a valuable diagnostic and prognostic marker for lung adenocarcinoma (LUAD).

Keywords:
biomarkerdiagnosisdynamic monitoringhsa_tsr011468lung adenocarcinoma

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Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Transfer RNA-derived small RNAs (tsRNAs) are emerging non-coding RNAs implicated in disease pathogenesis.
  • The role of tsRNAs in lung adenocarcinoma (LUAD) remains underexplored.
  • Identifying novel biomarkers for early LUAD detection is crucial.

Purpose of the Study:

  • To investigate the diagnostic and prognostic potential of the tsRNA hsa_tsr011468 in lung adenocarcinoma.
  • To evaluate hsa_tsr011468 as a potential serum biomarker for LUAD.

Main Methods:

  • tsRNA screening using the OncotRF database.
  • Quantitative detection of hsa_tsr011468 expression via reverse transcription-quantitative PCR (RT-qPCR) in serum and tissues.
  • Diagnostic and prognostic value assessment using receiver operating characteristic (ROC) curves and survival analyses.
  • Correlation analysis with clinicopathological parameters.
  • Subcellular localization studies of hsa_tsr011468.

    • Main Results:

    • The OncotRF database indicated high expression of hsa_tsr011468 in LUAD.
    • RT-qPCR confirmed elevated hsa_tsr011468 levels in serum and tissues of LUAD patients compared to controls.
    • hsa_tsr011468 expression decreased post-surgery.
    • ROC and survival analyses demonstrated significant diagnostic and prognostic value for hsa_tsr011468.
    • hsa_tsr011468 expression correlated with tumor size.
    • hsa_tsr011468 was primarily found in the cytoplasm of LUAD cells.

    Conclusions:

    • hsa_tsr011468 exhibits significant diagnostic and prognostic capabilities for lung adenocarcinoma.
    • hsa_tsr011468 serves as a potential non-invasive serum biomarker for LUAD detection and monitoring.
    • Further research into tsRNAs could reveal new therapeutic targets for LUAD.