Acetate-producing bacterium Paenibacillus odorifer hampers lung cancer growth in lower respiratory tract: an in vitro study
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View abstract on PubMed
Summary
This summary is machine-generated.The bacterium Paenibacillus odorifer in the lower airways may inhibit lung cancer by producing acetic acid. This microbe is found more in healthy lungs, suggesting a potential probiotic strategy for lung cancer prevention.
Area Of Science
- Microbiology
- Oncology
- Pulmonary Medicine
Background
- Lung cancer remains a leading cause of cancer mortality worldwide.
- The gut microbiome influences oncogenesis, but the role of lower airway microbes is less understood.
- Microbial metabolites in the respiratory tract may modulate lung cancer progression.
Purpose Of The Study
- To identify protective microbes in the lower airways and their role in lung cancer.
- To investigate the potential of Paenibacillus odorifer as a probiotic for lung cancer prevention.
- To explore the relationship between Paenibacillus odorifer, acetic acid, and lung cancer cell growth.
Main Methods
- Bioinformatics analysis of sequencing data and microbiome databases.
- Bacterial cultivation and in vitro verification of Paenibacillus odorifer.
- Multi-omics analysis of lower respiratory tract microbiome and short-chain fatty acids (SCFAs).
- Colony formation assays to assess lung cancer cell growth inhibition.
Main Results
- Paenibacillus odorifer was identified and correlated with acetic acid in the lower respiratory tract.
- This bacterium was enriched in healthy lung tissue compared to lung neoplasms.
- Paenibacillus odorifer inhibited lung cancer cell growth in a time- and dose-dependent manner.
- Acetic acid produced by Paenibacillus odorifer showed anti-tumorous effects.
Conclusions
- Paenibacillus odorifer acts as a potential probiotic in the lower airways.
- It restricts lung cancer cell growth by releasing protective molecules like acetic acid.
- This suggests a promising microbial strategy for lung cancer prevention and intervention.
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