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[SARIFA-a new multi-entity biomarker]
Bianca Grosser1, Nic G Reitsam1, Przmyslaw Grochowski1
1Institut für Pathologie und Molekulare Diagnostik, Medizinische Fakultät Augsburg, Universitätsklinikum Augsburg, Stenglinstraße 2, 86156, Augsburg, Deutschland.
Abstract:
A stroma a‑reactive invasion front area (SARIFA) is a new prognostic biomarker in carcinomas. Essentially, SARIFA describes the occurrence of direct contact between at least five tumor cells and adipocytes. This phenomenon is extremely easy and quick to identify, shows an extremely low interobserver variability, and does not require any additional staining as it can be identified on standard HE sections. The prognostic efficiency has now been demonstrated in gastric, colorectal, pancreatic, and prostate carcinoma.
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