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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

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Published on: August 20, 2019

[Post-COVID-19 condition-Clinical phenotyping in practice].

Karen Humkamp¹, Ana Sofia Costa¹, Kathrin Reetz¹

¹Klinik für Neurologie, Uniklinik RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland.

|October 4, 2024

Summary

A new subtype classification for post-COVID-19 condition (PCC) aids tailored treatment. Identifying at-risk patients early and implementing preventative strategies are crucial for managing neurological impairments in PCC.

Keywords:

Depression Fatigue Long-term effects Neuropsychology Subtypes

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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

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Published on: July 24, 2019

Area of Science:

Neurology
Infectious Diseases
Psychiatry

Context:

Post-COVID-19 condition (PCC) presents diverse neurological impairments challenging outpatient care.
Heterogeneity in PCC necessitates refined diagnostic and therapeutic approaches.
Existing guidelines for Long/Post-COVID require evaluation for clinical applicability.

Purpose:

To assess the utility of proposed "Long/Post-COVID" subtypes for phenotyping PCC patients.
To evaluate subtype applicability using clinical and neuropsychological data from a post-COVID clinic.
To refine PCC classification by incorporating a fifth subtype based on updated guidelines.

Summary:

A study of 157 patients identified five PCC subtypes based on clinical and neuropsychological evaluations.
Subtypes varied in demographics, symptom profiles (e.g., cognitive impairment, fatigue, affective symptoms), and pre-existing conditions.
Subtype 1 (postintensive care syndrome) had high BMI and word-finding issues; Subtype 2 (secondary diseases) showed cognitive impairment and depression; Subtype 3 (fatigue) was most common; Subtype 4 (exacerbation) presented affective symptoms; Subtype 5 had minimal complaints.

Impact:

Standardized subtype classification can improve individualized PCC treatment strategies.
Early identification of at-risk patients and preventative education at the primary care level are recommended.
Monitoring cardiovascular risk factors, promoting physical activity, and early psychotherapeutic/pharmacological interventions are key for PCC management.