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Related Concept Videos

  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Prognostic Role Of Whole-body Volumetric Positron Emission Tomography/computed Tomography Parameters In Treatment Naive Colorectal Cancer Patients With Liver Metastases.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Prognostic Role Of Whole-body Volumetric Positron Emission Tomography/computed Tomography Parameters In Treatment Naive Colorectal Cancer Patients With Liver Metastases.

Related Experiment Video

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The prognostic role of whole-body volumetric positron emission tomography/computed tomography parameters in treatment naive colorectal cancer patients with liver metastases.

Hüseyin Karaoğlan1, Ferat Kepenek, Halil Kömek

  • 1Department of Nuclear Medicine, Saglik Bilimleri University Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey.

Nuclear Medicine Communications
|October 4, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

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Primary tumor metabolic tumor volume (PMTV) from 18F-fluorodeoxyglucose PET/CT is a significant predictor of survival in colorectal liver metastasis (CLM) patients. This quantitative imaging marker offers valuable prognostic information for treatment-naive CLM.

Area of Science:

  • Oncology
  • Radiology
  • Medical Imaging

Background:

  • Colorectal liver metastasis (CLM) presents a significant challenge in cancer management.
  • Quantitative imaging parameters from 18F-fluorodeoxyglucose Positron Emission Tomography/computed tomography (FDG PET/CT) may offer prognostic insights.

Purpose of the Study:

  • To evaluate the prognostic value of quantitative FDG PET/CT parameters, including maximum standardized uptake value (SUV max), metabolic tumor volume (MTV), and total lesion glycolysis (TLG).
  • To assess these parameters in primary tumors, lymph node metastases, and liver metastases in patients with CLM.

Main Methods:

  • Retrospective analysis of 66 CLM patients (January 2017 - December 2018).
  • Quantitative PET/CT parameters (SUV max, MTV, TLG) were measured for primary tumors, lymph nodes, and liver metastases.
  • Univariate and multivariate Cox regression analyses were performed to determine prognostic factors for overall survival.

    • Main Results:

    • Univariate analysis identified primary tumor MTV (PMTV), lymph node MTV (LnMTV), lymph node TLG (LnTLG), lymph node SUV max (LnSUV max), and total TLG (TTLG) as significant prognostic factors for overall survival.
    • Primary tumor MTV (PMTV) emerged as an independent prognostic factor in multivariate analysis.
    • No significant association was found between liver metastasis MTV/TLG and overall survival.

    Conclusions:

    • Primary tumor metabolic tumor volume (PMTV) is an independent prognostic factor for survival in treatment-naive CLM patients.
    • Quantitative FDG PET/CT parameters, particularly PMTV, can aid in prognostic assessment for CLM.
    • Further validation with larger patient cohorts is recommended.