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Intact Fish Skin Graft to Treat Deep Diabetic Foot Ulcers.

Dured Dardari1,2, Alberto Piaggesi3, Louis Potier4,5

  • 1Diabetology Department, Center Hopitalier Sud Francilien, Corbeil-Essonnes, France.

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|October 4, 2024
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Summary

Intact fish skin grafts significantly improved healing rates for deep diabetic foot ulcers compared to standard care. This innovative treatment also accelerated the time to wound closure in patients with these challenging ulcers.

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Area of Science:

  • Regenerative Medicine
  • Wound Healing
  • Diabetic Complications

Background:

  • Diabetic foot ulcers are chronic, difficult-to-heal wounds with severe consequences.
  • Ulcers penetrating to bone or tendon present unique challenges in treatment.
  • Limited medical devices have been evaluated for these deep diabetic ulcers.

Purpose of the Study:

  • To evaluate the efficacy of intact fish skin graft versus standard wound care for diabetic ulcers.
  • To assess the proportion of healed ulcers at 16 weeks and time to healing.

Main Methods:

  • An international, open-label randomized controlled trial was conducted.
  • Patients with diabetic ulcers penetrating to bone, joint, or tendon were randomized 1:1.
  • Treatment involved intact fish skin graft or standard wound care for 14 weeks, with healing assessed at 16, 20, and 24 weeks.

Main Results:

  • Intact fish skin graft healed 44% of ulcers by 16 weeks, versus 26% for standard care (P<0.001).
  • Faster time to healing was observed with fish skin graft (mean 17.3 weeks vs. 19.4 weeks).
  • Primary wound infections were the most common adverse event in both groups.

Conclusions:

  • Intact fish skin graft is superior to standard care for healing deep diabetic foot ulcers.
  • Fish skin graft treatment accelerates the time to wound healing.
  • This suggests a promising therapeutic option for complex diabetic foot conditions.