Related Experiment Video
Updated: Apr 30, 2026
Bone Conditioned Medium: Preparation and Bioassay
Published on: July 8, 2015
An Organic Mineral Adhesive Bone Graft: A Preclinical Study
Purpose:
To evaluate four formulations of tetracalcium phosphate combined with phosphoserine (TTCP-PS) in comparison to the conventional grafting materials bioglass (BG) and deproteinized cancellous bovine bone with a bioresorbable collagen membrane in standardized defects created in the angle of the rat mandible.
Materials And Methods:
TTCP-PS is a synthetic, injectable, cohesive, self-setting, mineral-organic wet-field adhesive. Microcomputed tomography (microCT) and histomorphometry were used to evaluate bone replacement with each of these materials after in vivo residence of either 4 or 12 weeks.
Results:
Specific TTCP-PS formulations can form bone comparable to conventional materials in an osteopromotive mechanism but with the advantage of having cohesive and adhesive properties.
Conclusions:
This study showed the potential for TTCP-PS to be used as a viable candidate for bone grafting procedures.
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