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Allosteric Proteins-ATCase01:19

Allosteric Proteins-ATCase

Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis pathway,...
C–C Bond Cleavage: Retro-Aldol Reaction00:57

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The reverse of the aldol addition reaction is called the retro-aldol reaction. Here, the carbon–carbon bond in the aldol product is cleaved under acidic or basic conditions to form two molecules of carbonyl compounds. The mechanism of the reaction consists of three steps.
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Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Open and closed-loop control systems01:17

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Control systems are foundational elements in automation and engineering. They are broadly categorized into open-loop and closed-loop systems. These classifications hinge on the presence or absence of feedback mechanisms, significantly influencing the system's performance, complexity, and application.
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Feedback control systems are categorized in various ways based on their design, analysis, and signal types.
Linear feedback systems are theoretical models that simplify analysis and design. These systems operate under the principle that their output is directly proportional to their input within certain ranges. For instance, an amplifier in a control system behaves linearly as long as the input signal remains within a specific range. However, most physical systems exhibit inherent nonlinearity...
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In brick wall construction, supporting structures are crucial for openings like windows and doors to maintain the integrity and support the weight of the wall above. These supports include lintels, corbels, and arches, each serving specific structural purposes.
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BioMEMS and Cellular Biology: Perspectives and Applications
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Reply to C. Fuchao et al

Sabashini K Ramchand1, Ego Seeman1, Rudolf Hoermann1

  • 1Sabashini K. Ramchand, MBBS, BMedSci, FRACP, Department of Medicine, Austin Health, University of Melbourne, Melbourne, VIC, Australia; Ego Seeman, MD, MBBS, AO, FRACP, Department of Medicine, Austin Health, University of Melbourne, Melbourne, VIC, Australia, Department of Endocrinology, Austin Health, University of Melbourne, Melbourne, VIC, Australia; Rudolf Hoermann, MD, PhD, Department of Medicine, Austin Health, University of Melbourne, Melbourne, VIC, Australia; Ali Ghasem-Zadeh, PhD, MSc, Department of Medicine, Austin Health, University of Melbourne, Melbourne, VIC, Australia, Department of Endocrinology, Austin Health, University of Melbourne, Melbourne, VIC, Australia; and Mathis Grossmann, MD, PhD, FRACP, Department of Medicine, Austin Health, University of Melbourne, Melbourne, VIC, Australia.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|October 4, 2024
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No abstract available in PubMed .

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