Characterizing the genomic landscape through the lens of FOLR1 status in low and high grade serous ovarian carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Folate receptor alpha (FOLR1) is present in some low-grade serous ovarian carcinomas (LGSOC), suggesting it may be a viable therapeutic target for this rare cancer, especially when it recurs.
Area Of Science
- Oncology
- Genomics
- Translational Research
Background
- Targeted therapy for folate receptor alpha (FOLR1)-positive high-grade serous ovarian carcinoma (HGSOC) is established for platinum-resistant disease.
- Low-grade serous ovarian carcinoma (LGSOC) has a poorly documented FOLR1-positivity rate and responds poorly to conventional chemotherapy, necessitating new therapeutic targets.
Purpose Of The Study
- To assess the genomic and transcriptomic landscapes of FOLR1-positive and negative LGSOC.
- To compare these landscapes with their high-grade counterparts (HGSOC).
Main Methods
- Utilized a large precision oncology database for next-generation sequencing and immunohistochemistry on 281 LGSOC and 5086 HGSOC samples.
- Calculated MAPK activation using NGS data and performed survival analysis stratified by molecular alterations.
Main Results
- HGSOC showed higher FOLR1+ (43.5%) and PD-L1+ status compared to LGSOC (24.6%).
- LGSOC exhibited higher KRAS/NRAS mutations and lower BRAF mutations than HGSOC.
- MAPK activation was higher in LGSOC, but no difference was observed between FOLR1+ and FOLR1- LGSOC.
Conclusions
- A significant subset of LGSOC cases express FOLR1, indicating its potential as a therapeutic target.
- FOLR1 expression in LGSOC warrants further investigation for targeted treatment strategies, particularly for recurrent disease.
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