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Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Textbook Oncologic Outcome Is An Easy-to-use Composite Quality Measure That Is Strongly Associated With Survival In Advanced-stage Ovarian Cancer.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Textbook Oncologic Outcome Is An Easy-to-use Composite Quality Measure That Is Strongly Associated With Survival In Advanced-stage Ovarian Cancer.

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Textbook oncologic outcome is an easy-to-use composite quality measure that is strongly associated with survival in advanced-stage ovarian cancer.

Giuseppe Caruso1, Carrie L Langstraat2, Amanika Kumar2

  • 1Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mayo Clinic, Rochester, MN, USA; Division of Gynecologic Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.

Gynecologic Oncology
|October 4, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Achieving Textbook Oncologic Outcome (TOO) in advanced epithelial tubo-ovarian cancer (AEOC) surgery significantly improves 5-year survival for both primary debulking surgery and interval debulking surgery patients. This quality measure aids in assessing patient outcomes and guiding treatment decisions.

Keywords:
Advanced ovarian cancerDebulking surgeryOutcome measureQuality of care

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Gynecologic Oncology

Background:

  • Textbook Oncologic Outcome (TOO) is a validated quality measure in surgical oncology.
  • TOO correlates with improved oncologic outcomes.
  • Its association with survival in advanced epithelial tubo-ovarian cancer (AEOC) requires further assessment.

Purpose of the Study:

  • To evaluate the association between achieving TOO and overall survival (OS) in patients with AEOC.
  • To analyze this association separately for primary debulking surgery (PDS) and interval debulking surgery (IDS) cohorts.

Main Methods:

  • Retrospective analysis of 21,657 AEOC patients from the National Cancer Database (2008-2019).
  • TOO defined by complete debulking, short hospital stay (<10 days), no 30-day readmission, no 90-day mortality, and timely adjuvant chemotherapy initiation (≤42 days).
Survival
Textbook outcome
  • Kaplan-Meier and Cox regression analyses were used to assess 5-year OS by TOO status.

    • Main Results:

    • TOO was achieved in 20.5% of PDS patients and 39.2% of IDS patients.
    • Achieving TOO was linked to significantly improved 5-year OS in both PDS (59.0% vs. 39.5%) and IDS (43.9% vs. 31.2%) cohorts.
    • Multivariable analysis confirmed that achieving TOO reduced the risk of 5-year mortality in both surgical groups.

    Conclusions:

    • The TOO composite measure is strongly associated with improved long-term survival in AEOC patients.
    • TOO serves as a valuable quality assessment tool for primary treatment of AEOC, regardless of surgical approach.
    • This metric reflects effective risk-based, individualized care delivery through a multidisciplinary approach.