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Contrast-Enhanced Stereotactic Biopsy (CESB): Patient selection and practical considerations.
M B I Lobbes1, J Theunissen1, A Valentijn-Morsing1
1Zuyderland Medical Center, Department of Medical Imaging, Sittard-Geleen, the Netherlands.
European Journal of Radiology
|October 4, 2024
Summary
Contrast-enhanced mammography (CEM) is a valuable breast imaging tool, comparable to MRI. A new technique, contrast-enhanced stereotactic biopsy (CESB), provides an alternative for diagnosing
Area of Science:
- Breast Imaging
- Interventional Radiology
- Oncology
Background:
- Contrast-enhanced mammography (CEM) has emerged as a significant diagnostic tool in breast imaging since 2012.
- CEM demonstrates diagnostic accuracy comparable to breast MRI, offering a cost-effective alternative, particularly where MRI access is limited.
Purpose of the Study:
- To review the emerging technique of contrast-enhanced stereotactic biopsy (CESB) for diagnosing 'CEM-only' lesions.
- To outline patient selection criteria, procedural details, and key considerations for CESB.
- To provide an overview of the current literature on CESB.
Main Methods:
- This narrative review synthesizes current literature on contrast-enhanced stereotactic biopsy (CESB).
- It covers patient selection, procedural steps, and essential considerations for performing CESB.
- The review examines the role of CESB as an alternative to MRI-guided biopsy for specific breast lesions.
Main Results:
- CEM can identify 'CEM-only' lesions, which lack corresponding findings on other imaging modalities.
- MRI-guided biopsy is the current standard for these lesions.
- Contrast-enhanced stereotactic biopsy (CESB) has become commercially available since 2020 as a new alternative.
Conclusions:
- CESB presents a viable and potentially more accessible alternative for biopsy of 'CEM-only' lesions identified on contrast-enhanced mammography.
- Further research and clinical experience will solidify the role of CESB in breast cancer diagnosis.
- This review provides a foundational understanding for clinicians considering or implementing CESB.

