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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
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The role of JNK signaling pathway in organ fibrosis

Zhouhui Yao1, Yandan Lu2, Pingping Wang2

  • 1School of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China; Songyang Research Institute of Zhejiang Chinese Medical University, Songyang, 323400, China.

Journal of Advanced Research
|October 4, 2024
PubMed
Abstract

Insights

Fibrosis, a damaging tissue repair response, lacks effective treatments. This review explores how the JNK signaling pathway contributes to organ fibrosis, suggesting it as a potential therapeutic target.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Pathology

Background:

  • Fibrosis is a detrimental tissue repair response to injury, leading to organ damage and failure.
  • Current treatments for fibrosis are limited, highlighting the need for novel therapeutic strategies.
  • The c-Jun N-terminal kinase (JNK) signaling pathway is implicated in various cellular processes and is increasingly linked to fibrotic diseases.

Purpose of the Study:

  • To review the molecular mechanisms of JNK signaling in organ fibrosis.
  • To explore the potential of targeting the JNK pathway for novel anti-fibrotic therapies.

Main Methods:

  • Literature review of studies investigating JNK signaling in fibrosis.
  • Analysis of molecular pathways modulated by JNK in fibrotic conditions.

Main Results:

  • JNK signaling pathway regulates inflammation, immune responses, and oxidative stress in fibrosis.
  • Abnormal JNK pathway regulation is strongly associated with the development and progression of organ fibrosis.
  • JNK pathway modulates multiple cellular functions critical to fibrotic processes.

Conclusions:

  • Targeting the JNK signaling pathway presents a promising therapeutic strategy for treating organ fibrosis.
  • Understanding JNK's role in fibrosis could lead to the development of effective anti-fibrotic drugs.
  • Further research into JNK pathway modulation may offer new hope for patients suffering from fibrotic diseases.
Keywords:
JNK signaling pathwayMolecular mechanismOrgan fibrosisSmall-molecule inhibitorTreatment strategy

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