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Related Experiment Video

Updated: Jun 11, 2025

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells

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HER3: Updates and current biology function, targeted therapy and pathologic detecting methods.

Leyi Gao¹, Yu Zhang¹, Mengna Feng¹

¹Department of Pathology, West China Hospital, Sichuan University, No.37, Guo Xue Xiang, Chengdu 610041, Sichuan, China.

|October 4, 2024

Summary

This summary is machine-generated.

Human HER3 (human epidermal growth factor receptor 3) is overexpressed in many cancers, driving tumor growth and drug resistance. This review covers HER3

Keywords:

Breast cancer ERBB3 HER3 Oncology Pathological detecting methods

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Area of Science:

Oncology
Molecular Biology
Cancer Research

Background:

HER3 (human epidermal growth factor receptor 3) is a member of the EGFR tyrosine kinase family, frequently overexpressed in cancers like breast cancer.
Despite low intrinsic kinase activity, HER3 heterodimerizes with partners (e.g., HER2) to activate pro-carcinogenic signaling pathways, promoting cell migration, survival, and proliferation.
HER3 overexpression correlates with tumor invasion, metastasis, and poor patient prognosis.

Purpose of the Study:

To review the multifaceted role of HER3 in cancer, including its relationship with overexpression, mutations, carcinogenicity, and therapeutic resistance.
To elucidate the unique structural and kinase activity characteristics of HER3.
To catalog emerging HER3-targeted therapies and contrast common clinical detection methods for HER3 in pathology.

Main Methods:

Literature review and synthesis of existing research on HER3.
Analysis of HER3 structure, function, and signaling pathways in cancer.
Compilation and comparison of current and investigational HER3-targeted therapeutic strategies.
Review of pathological detection methods for HER3 expression.

Main Results:

HER3's unique structure and low kinase activity necessitate heterodimerization for signaling, contributing to cancer progression.
HER3 overexpression is a significant driver of tumor invasion, metastasis, and resistance to certain therapies.
A growing pipeline of HER3-targeted drugs is under clinical investigation, showing promise for improved cancer treatment.
Various clinical detection methods for HER3 exist, each with specific applications in pathology.

Conclusions:

Understanding HER3's mechanisms in tumors is crucial for improving cancer patient outcomes.
Advancements in targeted HER3 therapy hold significant potential to enhance the efficacy of anticancer treatments.
Targeted HER3 therapies, alongside accurate detection methods, offer a promising avenue for improving cancer prognosis.