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Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
Published on: January 27, 2014
Functional and pathological roles of adenylyl cyclases in various diseases
Ying Gao1, Yanqun Luo2, Guang Ji3
1Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Abstract:
Adenylyl cyclases (ADCYs) produce the second messengers cAMP, which is crucial for a number of cellular activities. There are ten isoforms in the mammalian ADCY family including nine transmembrane adenylyl cyclases (tmAC) and one soluble adenylyl cyclase (sAC/ADCY10). There have been numerous studies demonstrating the importance of ADCYs in the development of a wide range of diseases, including cardiovascular disease, neurological disease, liver disease, and tumors. The classification, structure and regulation of ADCYs are discussed in this overview, which is followed by an analysis of how ADCYs are involved in various disorders and how they are used as a therapeutic tool. Our objective is to get a more thorough understanding of ADCYs to aid future study and provide novel ideas for the treatment of particular diseases.
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