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Enhanced drug release through nitrendipine/hydroxypropyl methylcellulose solid dispersion via supercritical

Jianxia Hao1, Ning Zhu1, Lijun Song1

  • 1College of Chemical Engineering, Inner Mongolia University of Technology, Hohhot 010051, China; Inner Mongolia Engineering Research Center for CO(2) Capture and Utilization, Hohhot 010051, China; Key Laboratory of CO(2) Resource Utilization at Universities of Inner Mongolia Autonomous Region, Hohhot 010051, China.

International Journal of Biological Macromolecules
|October 4, 2024
PubMed
Summary

Supercritical antisolvent technology created nitrendipine/hydroxypropyl methylcellulose solid dispersions. This enhanced drug solubility and bioavailability, offering a promising delivery system with good biocompatibility.

Keywords:
Hydroxypropylmethyl celluloseNitrendipineSolid dispersion，DissolutionSupercritical antisolvent

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