Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ia determinants on macrophages.

P Erb

    Comparative Immunology, Microbiology and Infectious Diseases
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    T cells require antigen presented with I-region associated (Ia) determinants for activation, highlighting the crucial role of Ia expression on antigen-presenting cells in immune responses.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of antiretroviral therapy on apoptosis markers and morphology in peripheral lymph nodes of HIV-infected individuals.

    Infection·2008
    Same author

    Gli2 upregulates cFlip and renders basal cell carcinoma cells resistant to death ligand-mediated apoptosis.

    Oncogene·2008
    Same author

    Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study.

    British journal of cancer·2006
    Same author

    Fas-ligand gene silencing in basal cell carcinoma tissue with small interfering RNA.

    Gene therapy·2005
    Same author

    Combined therapy with saquinavir, ritonavir and stavudine in moderately to severely immunosuppressed HIV-infected protease inhibitor-naive patients.

    HIV medicine·2001
    Same author

    A single-nucleotide polymorphism in the sterol-regulatory element-binding protein 1c gene is predictive of HIV-related hyperlipoproteinaemia.

    AIDS (London, England)·2001
    Same journal

    Detection of SARS-CoV-2 and coinfections in companion animals from COVID-19-positive owners in Southeast, Brazil.

    Comparative immunology, microbiology and infectious diseases·2026
    Same journal

    Screening candidate intermediate hosts for porcine respiratory coronavirus using molecular docking.

    Comparative immunology, microbiology and infectious diseases·2026
    Same journal

    Comparison of Igκ and Igλ binding toward influenza virus hemagglutinin and SARS-CoV-2 Spike protein during primary viral infections in humans, mice, and pigs.

    Comparative immunology, microbiology and infectious diseases·2026
    Same journal

    Complete genome and phenotypic characterization of a feline-derived Bartonella henselae strain with enhanced endothelial interaction and immunomodulatory phenotypes.

    Comparative immunology, microbiology and infectious diseases·2026
    Same journal

    Susceptibility or resistance to Bartonella spp. infection in cats: Does the phenotype-B blood matter?

    Comparative immunology, microbiology and infectious diseases·2026
    Same journal

    Experimental infection of laying hens with Campylobacter coli and Campylobacter jejuni: Shedding dynamics and internal organ colonization.

    Comparative immunology, microbiology and infectious diseases·2026
    See all related articles

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • T cell activation necessitates antigen presentation alongside I-region associated (Ia) determinants.
    • Antigen-presenting cells (APCs) and accessory cells are crucial for immune responses and characteristically express Ia determinants.
    • Ia expression was initially identified on B cells and macrophages but is now recognized on a broader range of cell types.

    Purpose of the Study:

    • To explore the correlation between accessory cell function and Ia expression.
    • To understand the regulatory mechanisms of Ia expression on accessory cells.
    • To investigate the potential role of Ia molecules as products or mediators of immune response (Ir) genes.

    Main Methods:

    • Review of established immunological principles and findings.
    • Analysis of cell surface marker expression (Ia positivity).

    Related Experiment Videos

  • Examination of factors influencing Ia expression, such as phagocytosis, gamma-interferon, prostaglandin E, and alpha-fetoprotein.

    • Main Results:

    • A strong correlation exists between accessory cell function and Ia expression.
    • Phagocytosis and gamma-interferon induce Ia expression, while prostaglandin E and alpha-fetoprotein down-regulate it in macrophages.
    • Not all Ia-positive cells are equally capable of activating all T cell functions.

    Conclusions:

    • Ia expression on accessory cells is a key regulatory component of immune responses.
    • Ia molecules are likely products or mediators of immune response (Ir) genes within the major histocompatibility complex.
    • The ability of Ia-positive cells to activate T cells varies, suggesting functional heterogeneity.