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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
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Tumor characteristics in immunosuppressed and renal dysfunction populations
Benjamin I Joffe1, Luis Pina Martina1, Mason Stillman2
1Department of Urology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY.
Urologic Oncology
|October 4, 2024
Summary
Patients with end-stage renal disease or kidney transplants do not have a higher risk of aggressive kidney cancer. Renal dysfunction and immunosuppression did not correlate with aggressive tumor pathology in this study.
Area of Science:
- Nephrology
- Oncology
- Transplant Surgery
Background:
- Renal cell carcinoma (RCC) risk is elevated in patients with end-stage renal disease (ESRD) and kidney transplant recipients due to renal dysfunction and immunosuppression.
- Previous studies suggest RCC in these populations may be more indolent, but data are limited and conflicting.
Purpose of the Study:
- To investigate the histological characteristics of renal tumors in patients with ESRD or undergoing renal transplantation.
- To compare the aggressiveness of renal tumors in this cohort with a control population.
Main Methods:
- A retrospective cohort study analyzed nephrectomies performed between 2009 and 2019.
- Patients were categorized based on renal transplant status and ESRD diagnosis, confirmed via chart review.
- Tumors were classified as aggressive or non-aggressive based on histology and grade.
Main Results:
- Of 1,057 eligible nephrectomies, 68 patients (6.4%) had ESRD or a kidney transplant.
- 25% of tumors were classified as aggressive, and 64% were pT1a or pT1b.
- Multivariable analysis revealed no significant association between renal dysfunction and aggressive tumor pathology (OR 1.24, P=0.44).
Conclusions:
- No relationship was observed between renal dysfunction status and aggressive renal tumor pathology.
- Patients with ESRD or kidney transplants appear to have a similar risk of aggressive pathology as the general population.
- Management guidelines for renal tumors in ESRD and transplant patients should align with those for the general population.
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