[Several critical aspects of the value of peripheral markers in depression (TRH test and dexamethasone depression)]

Studies of depression carried out for over 10 years have led to the discovery of biological tracers for depression. The authors have performed numerous TRH and dexamethasone tests and in their opinion, the present enthusiasm for these tests should be tempered. In several aspects the various values attributed to them seem to be questionable. Owing to the difficulty in codifying these tests, the authors question their diagnostic, pronostic, therapeutic and predictive values. The authors' own experience as well as the evolution of the publications throughout the world have been taken into consideration. Finally, the problem of interferences and the doubtful specificity of endocrine tests for depression have been dealt with.