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Evaluating post-thrombectomy effective connectivity changes in anterior circulation stroke.

Jiaona Xu1, Weiwei Chen2, Guozhong Niu3

  • 1Department of Rehabilitation, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, China.

Annals of Clinical and Translational Neurology
|October 5, 2024
PubMed
Summary
This summary is machine-generated.

Acute ischemic stroke (AIS) patients show altered brain connectivity after mechanical thrombectomy (MT). The caudate nucleus plays a key role in functional remodeling within the cortico-basal ganglia-thalamic-cortical pathway post-MT.

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Area of Science:

  • Neuroscience
  • Radiology
  • Neurology

Background:

  • Granger causal analysis (GCA) and amplitude of low-frequency fluctuation (ALFF) are established methods for assessing brain function.
  • Understanding functional alterations in acute ischemic stroke (AIS) is crucial for effective treatment and recovery.

Purpose of the Study:

  • To investigate effective connectivity (EC) changes in AIS patients with anterior circulation occlusion post-mechanical thrombectomy (MT) using GCA and ALFF.
  • To explore the relationship between EC, ALFF, and clinical outcomes in AIS patients.

Main Methods:

  • Resting-state functional magnetic resonance imaging (rs-fMRI) data from 43 AIS patients and 37 healthy controls were analyzed.
  • ALFF and GCA were computed; patients were subgrouped by prognosis and perfusion.
  • EC and ALFF differences were compared between groups, and correlations with clinical data were assessed.

Main Results:

  • AIS patients exhibited altered ALFF in the precuneus, fusiform gyrus, and caudate post-MT compared to controls.
  • Significant changes in EC were observed, particularly involving the caudate nucleus, with notable differences between perfusion groups.
  • EC values correlated with National Institutes of Health Stroke Scale (NIHSS) scores.

Conclusions:

  • The caudate nucleus is central to functional remodeling in AIS patients post-MT, showing altered input/output patterns.
  • These findings highlight dynamic changes within the cortico-basal ganglia-thalamic-cortical pathway following stroke intervention.