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Related Experiment Videos

Exogenous androgens decrease the length of the luteal phase and increase the length of the follicular phase.

L J Gooren

    Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
    |December 1, 1985
    PubMed
    Summary

    Exogenous androgens shortened the luteal phase and lengthened the follicular phase in transsexual females. Despite testosterone, ovulation continued, suggesting a link between hyperandrogenism and luteal insufficiency.

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    Area of Science:

    • Endocrinology
    • Reproductive Health
    • Transgender Health

    Background:

    • The menstrual cycle is regulated by complex hormonal interactions.
    • Transsexual females undergoing hormone therapy may experience altered reproductive function.

    Purpose of the Study:

    • To investigate the impact of exogenous androgens on the menstrual cycle in transsexual females.
    • To explore the relationship between hyperandrogenism and luteal phase function.

    Main Methods:

    • Observational study of eight transsexual females.
    • Monitoring of menstrual cycle phases (luteal and follicular).
    • Measurement of blood levels for testosterone, estrogen, and progesterone; basal body temperature tracking.

    Main Results:

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    • The luteal phase duration decreased significantly (13.7 to 11.6 days).
    • The follicular phase duration increased significantly (13.5 to 15.3 days).
    • Ovulation persisted despite elevated testosterone levels, indicated by hormonal and temperature changes.

    Conclusions:

    • Exogenous androgens can disrupt normal menstrual cycle dynamics.
    • Hyperandrogenism in this context is associated with luteal insufficiency.
    • Further research is needed to understand the full implications for reproductive health in transgender individuals.