Noninvasive Left Ventricular Pressure-Strain Loop for Quantitative Assessment of Early Left Ventricular Systolic...

Area of Science:

• Cardiology
• Nephrology
• Biomedical Engineering

Background:

• Patients with chronic kidney disease (CKD) face elevated cardiovascular event risks.
• Subtle cardiac function changes can be detected using noninvasive left ventricular pressure-strain loop (LV-PSL) analysis.
• This study evaluates LV-PSL for quantitative myocardial work (MW) assessment in CKD patients.

Purpose of the Study:

• To investigate the utility of LV-PSL for quantitative assessment of myocardial work (MW) in patients with CKD.
• To compare MW parameters between CKD patients and healthy controls.
• To identify associations between MW parameters and clinical factors in CKD.

Main Methods:

• Retrospective enrollment of 75 CKD patients (Stages 2-5) and 35 healthy controls.
• Transthoracic echocardiography with LV-PSL analysis to estimate LV MW and efficiency.
• Quantification of global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE).

Main Results:

• CKD patients exhibited significantly higher GWW and lower GWE compared to controls (p < 0.05).
• No significant differences in GWI and GCW were found among the groups.
• Increased GWW correlated with age, serum creatinine, and systolic pressure; decreased GWE correlated with age, serum creatinine, and global longitudinal strain (GLS).

Conclusions:

• LV-PSL provides a noninvasive, quantitative method for assessing MW in CKD patients.
• This technique offers a sensitive new approach for clinical evaluation of myocardial function in CKD.
• Findings highlight potential for early detection of cardiac dysfunction in CKD through MW analysis.