Oral toxicity assessment and the mitigation of lung carcinogenesis by phytol and α-bisabolol combination treatment in swiss albino mice: insights into redox enzyme modulation and caspase-dependent cell death mechanisms
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View abstract on PubMed
Summary
This summary is machine-generated.Phytol and α-bisabolol combinations are safe and show potential anti-lung cancer effects. These compounds protect organs, boost antioxidant defenses, and influence apoptotic pathways, suggesting a role in lung cancer prevention and treatment.
Area Of Science
- Pharmacology and Toxicology
- Cancer Research
Background
- Lung cancer remains a leading cause of cancer-related mortality globally.
- Natural compounds are increasingly investigated for their chemopreventive and therapeutic potential.
- Phytol and α-bisabolol are plant-derived compounds with known biological activities.
Purpose Of The Study
- To evaluate the safety and anti-lung cancer properties of combined phytol and α-bisabolol.
- To assess the effects on oxidative stress and apoptosis in a lung cancer model.
Main Methods
- Acute and subacute toxicity studies in Swiss albino mice.
- Hematological, biochemical, and histopathological analyses.
- Assessment of antioxidant enzyme levels (GSH, SOD, CAT) and apoptosis-related proteins (Bax, Bcl-2, Caspase-3, Caspase-9) in a benzo(a)pyrene-induced lung cancer model.
Main Results
- Phytol and α-bisabolol combination demonstrated a high LD50 (>2000 mg/kg) and no observed toxicity in organs.
- The compounds normalized lung weight and alveolar epithelium structure in carcinogen-exposed mice.
- Significant modulation of antioxidant enzymes and apoptosis markers was observed, indicating protective effects against oxidative damage and promoting an anti-cancer environment.
Conclusions
- Combined phytol and α-bisabolol are safe, organ-protective, and exhibit no acute or subacute toxicity.
- These compounds modulate antioxidant defenses and apoptotic signaling pathways.
- Phytol and α-bisabolol show promise for the prevention and treatment of lung cancer.
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