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Periodontal ligament injection. An experimental study in the monkey
International Journal of Oral Surgery
|December 1, 1985
Summary
Local anesthetic injections into the periodontal ligament of monkeys caused temporary cell damage. However, tissues fully recovered within one week, indicating no long-term adverse effects from these dental anesthesia techniques.
Area of Science:
- Dental research
- Periodontology
- Pharmacology
Background:
- Periodontal ligament injections are used for local anesthesia in dentistry.
- Understanding the tissue response to these injections is crucial for patient safety.
Purpose of the Study:
- To investigate the histopathological effects of local anesthetic solutions injected into the periodontal ligament in a primate model.
- To compare the tissue reactions to different anesthetic agents and injection durations.
Main Methods:
- An experimental double-blind, cross-over study was conducted in monkeys.
- Lidocaine with adrenaline and mepivacaine were administered via periodontal ligament injection over 5 or 20 seconds.
- Histopathological analysis was performed immediately after injection and one week later.
Main Results:
- Immediate histopathological analysis revealed cell damage in tissues adjacent to the injection sites.
- Specimens examined one week post-injection showed complete normalization of the periodontal tissues.
Conclusions:
- Periodontal ligament injections of lidocaine with adrenaline and mepivacaine cause transient, localized cell damage.
- The periodontal tissues demonstrate complete healing and recovery within one week following the injection procedure.