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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
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Updated: Jun 11, 2025

Author Spotlight: Controlled Human Exposure Model for Tick Research and Lyme Disease Studies
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Pathogens transmitted by Ixodes ricinus.

Jeremy Gray1, Olaf Kahl2, Annetta Zintl3

  • 1UCD School of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland.

Ticks and Tick-Borne Diseases
|October 5, 2024
PubMed
Summary
This summary is machine-generated.

Ixodes ricinus ticks transmit numerous pathogens in Europe. This review clarifies evidence-based facts on tick-borne encephalitis virus, Borrelia burgdorferi, and other microbes, focusing on transmission and hosts.

Keywords:
Anaplasma phagocytophilumBabesia speciesBorrelia burgdorferi s.l.Ixodes ricinusLouping-ill virusReservoir hostsTick-borne encephalitis virusZoonotic tick-borne pathogens

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Area of Science:

  • Veterinary Entomology
  • Medical Entomology
  • Parasitology

Background:

  • Ixodes ricinus is a significant tick vector in Europe.
  • Published literature often conflates conjecture with confirmed facts regarding tick-borne pathogens.
  • Accurate information on tick-borne diseases is crucial for public health.

Purpose of the Study:

  • To provide evidence-based information on Ixodes ricinus and its transmitted pathogens.
  • To differentiate confirmed facts from conjecture regarding transmission cycles and clinical significance.
  • To review the development, transmission dynamics, and reservoir hosts of key tick-borne pathogens.

Main Methods:

  • Comprehensive literature review of Ixodes ricinus and associated pathogens.
  • Focus on well-researched human pathogens including tick-borne encephalitis virus, Borrelia burgdorferi sensu lato, and Babesia species.
  • Inclusion of less common pathogens and potential emerging threats.

Main Results:

  • Detailed information on the tick's role in pathogen development and transmission.
  • Identification of primary reservoir hosts for major tick-borne diseases.
  • Assessment of the evidence for less common pathogens and potential new threats transmitted by Ixodes ricinus.

Conclusions:

  • Ixodes ricinus is a critical vector for numerous pathogens in Europe.
  • Evidence-based understanding of transmission dynamics and host-pathogen interactions is essential.
  • This review consolidates current knowledge, highlighting areas needing further research.