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Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity: A systematic review and meta-analysis

  • 0University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.
Redox Biology +

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October 5, 2024

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October 5, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Oxidative stress is implicated in inflammatory bowel disease (IBD). Biomarkers indicate oxidative damage and reduced antioxidants in IBD patients, with specific markers differentiating disease activity in Crohn's disease and ulcerative colitis.

Area Of Science

  • Gastroenterology
  • Biochemistry
  • Molecular Biology

Background

  • Oxidative stress is a key factor in the pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC).
  • Understanding oxidative stress biomarkers can aid in disease management and monitoring.

Purpose Of The Study

  • To identify and quantify oxidative stress-related biomarkers in IBD patients.
  • To assess the association of these biomarkers with disease activity in CD and UC.

Main Methods

  • Systematic literature search of Ovid MEDLINE, Embase, and Web of Science databases.
  • Inclusion of 54 studies comparing active/inactive IBD with healthy controls, and active/inactive CD and UC.
  • Analysis of oxidative damage biomarkers and antioxidant levels.

Main Results

  • Patients with active and inactive IBD showed increased oxidative damage biomarkers and decreased antioxidants compared to healthy controls.
  • Specific biomarkers like malondialdehyde, Paraoxonase 1, catalase, albumin, transferrin, and total antioxidant capacity differentiated active from inactive CD.
  • Paraoxonase 1, erythrocyte glutathione peroxidase, catalase, albumin, transferrin, and free thiols differed between active and inactive UC.
  • Vitamins and carotenoids showed potential but require monitoring of intake.

Conclusions

  • Oxidative stress significantly contributes to IBD pathogenesis.
  • Oxidative stress biomarkers offer a potential minimally invasive tool for monitoring IBD activity.

Keywords:

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