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Benign prostatic hyperplasia genetic variants in Asians
Muhammad Mahbubi Sani1, Yudhistira Pradnyan Kloping2, Fakhri Surahmad3
1Faculty of Medicine, University of Surabaya, Surabaya 60292, Indonesia; Department of Urology, Jombang General Hospital, Jombang 61416, Indonesia.
Summary
This review highlights genetic screening for benign prostatic hyperplasia (BPH) in Asian populations. Identifying genetic variants like CYP17 rs743572 C can personalize BPH risk stratification and treatment.
Area of Science:
- Urology
- Genetics
- Oncology
Background:
- Benign prostatic hyperplasia (BPH) prevalence is rising globally, particularly in Asian populations.
- BPH significantly increases the risk of prostate cancer (2- to 12-fold).
- Existing clinical guidelines lack specific risk stratification for BPH in Asian demographics.
Purpose of the Study:
- To address the gap in genetic screening for BPH risk stratification in Asians.
- To develop pathophysiology insights based on identified genetic variants.
- To explore ethnic influences on BPH progression and its links to other diseases.
Main Methods:
- Review of existing literature on BPH genetics and epidemiology.
- Focus on genetic variants associated with BPH risk in Asian populations.
- Analysis of the CYP17 gene and its role in testosterone synthesis and BPH.
Main Results:
- The CYP17 rs743572 C allele is a genetic variant increasing BPH risk by 1.58 times in Asians.
- Genetic screening can enable tailored therapies based on individual genetic profiles.
- Ethnicity may influence BPH progression and its association with other conditions.
Conclusions:
- Genetic screening is crucial for accurate BPH risk stratification in Asian men.
- Understanding genetic variants can lead to personalized BPH management strategies.
- Further research into ethnic-specific BPH pathophysiology is warranted.
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